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R. RAJESH KANNAN, M. RAJASIMMAN, N. RAJAMOHAN, B. SIVAPRAKASH,
《环境科学与工程前沿(英文)》 2010年 第4卷 第1期 页码 116-122 doi: 10.1007/s11783-010-0006-7
关键词: Malachite green (MG) Turbinaria conoides marine algae equilibrium studies biosorption
Simulation studies on metastable phase equilibria in the aqueous ternary systems (NaCl-MgCl
Tianlong DENG, Baojun ZHANG, Dongchan LI, Yafei GUO
《化学科学与工程前沿(英文)》 2009年 第3卷 第2期 页码 172-175 doi: 10.1007/s11705-009-0048-1
关键词: green chemistry solar pond technique simulation metastable phase equilibrium solubility
《化学科学与工程前沿(英文)》 2022年 第16卷 第12期 页码 1700-1712 doi: 10.1007/s11705-022-2207-6
关键词: naphtha catalytic pyrolysis reaction pathway equilibrium yield
Measurement and correlation of the solid-liquid equilibrium of 2-(
Yanhong SUN, Zhiyong LI, Chuang XIE, Wei CHEN, Cui ZHANG
《化学科学与工程前沿(英文)》 2013年 第7卷 第1期 页码 110-115 doi: 10.1007/s11705-013-1316-7
关键词: solid-liquid equilibrium (SLE) eutectic integrated computer aided system (ICAS) TOPEM correlation
Genome-wide association studies: inherent limitations and future challenges
null
《医学前沿(英文)》 2012年 第6卷 第4期 页码 444-450 doi: 10.1007/s11684-012-0225-3
Genome-wide association studies (GWAS) have achieved great success in identifying genetic variants related to complex human diseases such as cancer and have provided valuable insights into their genetic architecture. Recently, GWAS is quite the fashion in China. However, there are issues related to its nature. Enormous work needs to be done in the post-GWAS era. Deep sequencing followed by functional studies will be needed to elucidate the underpinning biological mechanisms and further translate GWAS findings into medical practice. Along with pharmacogenomics, the success of GWAS in identifying genetic risk factors and genetic differences in drug response has been gradually enabling personalized medicine. In this article, we used hepatocellular carcinoma (HCC) as an example to demonstrate some of the inherent limitations and summarized future challenges of GWAS.
关键词: genome-wide association studies (GWAS) genetic variant cancer limitation challenge
Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia
null
《医学前沿(英文)》 2015年 第9卷 第1期 页码 1-9 doi: 10.1007/s11684-015-0381-3
With the cure rate of childhood acute lymphoblastic leukemia (ALL) approaching 90%, further improvement in the treatment outcome and quality of life of patients will require better understanding of the mechanisms of drug resistance, identifying new leukemic cell genetic lesions that are amendable to available target therapy, and optimizing treatment based on host pharmacodynamics and pharmacogenomics. Deeper characterization of leukemic cell genetic abnormalities has discovered new subtypes of leukemia such as early T-cell precursor ALL and Philadelphia chromosome-like ALL, and identified many genomic alterations that have diagnostic, prognostic, or therapeutic implications. In this regard, several novel fusion transcripts are responsive to ABL tyrosine kinase inhibitors and potentially to JAK inhibitors. Genome-wide analyses have also unraveled the role of inherited cancer predisposing genes and small nucleotide polymorphisms of several genes in the development of childhood ALL. These advances promise to lead to more sophisticated personalized treatment strategies in the near future.
关键词: pharmacogenomics acute lymphoblastic leukemia genomics pharmacogenetics
香蕉假茎作为吸附剂用于水溶液中铅离子去除的条件优化、动力学与吸附平衡研究 Article
Shridhar S. Bagali, Bychapur S. Gowrishankar, Aashis S. Roy
《工程(英文)》 2017年 第3卷 第3期 页码 409-415 doi: 10.1016/J.ENG.2017.03.024
香蕉假茎粉末等天然吸附剂对于去除废水中的重金属元素具有非常重要的作用。现有的去除重金属元素的常规方法难以满足水资源循环和化学工业的需求。本文论证了利用天然物质处理废水的可能性。利用环境扫描电子显微镜(ESEM) 和傅里叶变换红外(FTIR) 光谱学分析方法,研究了香蕉假茎粉末吸附铅离子前后的变化。实验采用批处理方法研究了水溶液中铅离子去除的效果。通过改变初始pH 值、吸附剂用量、初始铅离子浓度、吸附时间等参数,研究了吸附动力学的影响。结果表明,在水溶液pH 值为5.5 时,香蕉假茎粉末达到零电荷点。采用吸附等温线和动力学模型分析实验数据,采用朗缪尔吸附等温式拟合铅离子在香蕉假茎粉末表面的吸附作用。实验表明,香蕉假茎粉末对铅离子的吸附量为34.21 mg·g−1,与拟二级动力学模型相匹配。此外,采用响应面分析法确定了铅离子吸附的最佳条件,铅离子的去除率高达89%。
Non-equilibrium model for catalytic distillation process
WANG Feng, ZHAO Ning, LI Junping, XIAO Fukui, WEI Wei, SUN Yuhan
《化学科学与工程前沿(英文)》 2008年 第2卷 第4期 页码 379-384 doi: 10.1007/s11705-008-0071-7
《环境科学与工程前沿(英文)》 2021年 第15卷 第5期 doi: 10.1007/s11783-021-1397-3
• Synthesis of NS-CNTS is used in a high desulfurization performance.
关键词: Dibenzothiophene (DBT) Tertiary methyl mercaptan Adsorption Carbon nano tube (CNT) Desulfurization Doping
《环境科学与工程前沿(英文)》 2023年 第17卷 第8期 doi: 10.1007/s11783-023-1694-0
● Data quality assessment criteria for MP/NPs in food products were developed.
关键词: Microplastic Nanoplastic Food products Data quality Human health risk
何华武
《中国工程科学》 2009年 第11卷 第5期 页码 23-30
高速道岔是高速铁路轨道结构的关键,其结构与状态对列车运行安全和运行品质具有重大影响。文章介绍了高速道岔设计参数和平面线形,扣件、岔枕、道岔转换系统等部件主要结构特征,高速道岔设计理论,相关技术条件及取得的创新成果,对于中国高速铁路道岔的进一步研制、试验验证及推广使用具有重要的指导意义。
ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT
《农业科学与工程前沿(英文)》 2022年 第9卷 第1期 doi: 10.15302/J-FASE- 2021390
It has previously been shown that tryptophan, the biosynthesis precursor of Peganum harmala alkaloids, and its derivatives have anti-TMV activity both in vitro and in vivo. Further exploration of this led to the identification of NK0238 as a highly effective agent for the prevention and control of diseases caused by plant viruses, but the existing routes are unsuitable for its large-scale synthesis. This study optimized a route for two-step synthesis of this virucide candidate via reaction of l-tryptophan with triphosgene to produce l-tryptophan-N-carboxylic anhydride, which then reacts with n-octylamine to give NK0238 at up to 94% yield and nearly 97% HPLC purity. In addition, the route was used for the preparation of NK0238 on a>40 g scale permitting further assessment of its antivirus activity in the greenhouse and field experiments, and toxicity tests. NK0238 exhibited useful antiviral activities against a variety of viruses both in greenhouse and field experiments. The toxicity tests showed that NK0238 was not acutely toxic to birds, fish, honey bees and silkworms. The optimized route provides a solid foundation for its large-scale synthesis and subsequent efficacy and toxicity studies, its excellent activity and safety make NK0238 a promising drug candidate for further development.
Jianxian ZENG, Junfeng LIU, Niandong HUANG,
《化学科学与工程前沿(英文)》 2010年 第4卷 第3期 页码 360-366 doi: 10.1007/s11705-009-0269-3
Parameter studies on impact in a lap joint
Amir M. RAHMANI,Elizabeth K. ERVIN
《机械工程前沿(英文)》 2015年 第10卷 第1期 页码 64-77 doi: 10.1007/s11465-014-0322-x
To represent a loose lap joint, a beam impacting four springs with gaps is modeled. Modal analysis with base excitation is solved, and time histories of contact points are closely monitored. Using the impulse during steady state response, six influential parameters are studied: damping ratio, contact stiffness, intermediate contact position, gap, excitation amplitude and beam height. For all parameters, the system response is highly controlled by modes with two contacting springs. Each parameter’s effect on system response is presented including unstable regions, unique trend behaviours result. Recommendations for structural designers are also noted.
关键词: impact mechanics contact joint behaviour modal analysis parameter study
Experimental studies on the influence of porosity on membrane absorption process
GAO Jian, REN Zhongqi, ZHANG Zeting, ZHANG Weidong
《化学科学与工程前沿(英文)》 2007年 第1卷 第4期 页码 385-389 doi: 10.1007/s11705-007-0070-0
标题 作者 时间 类型 操作
Brown marine algae turbinaria conoides as biosorbent for Malachite green removal: Equilibrium and kinetic
R. RAJESH KANNAN, M. RAJASIMMAN, N. RAJAMOHAN, B. SIVAPRAKASH,
期刊论文
Simulation studies on metastable phase equilibria in the aqueous ternary systems (NaCl-MgCl
Tianlong DENG, Baojun ZHANG, Dongchan LI, Yafei GUO
期刊论文
Thermodynamic analysis of reaction pathways and equilibrium yields for catalytic pyrolysis of naphtha
期刊论文
Measurement and correlation of the solid-liquid equilibrium of 2-(
Yanhong SUN, Zhiyong LI, Chuang XIE, Wei CHEN, Cui ZHANG
期刊论文
香蕉假茎作为吸附剂用于水溶液中铅离子去除的条件优化、动力学与吸附平衡研究
Shridhar S. Bagali, Bychapur S. Gowrishankar, Aashis S. Roy
期刊论文
Non-equilibrium model for catalytic distillation process
WANG Feng, ZHAO Ning, LI Junping, XIAO Fukui, WEI Wei, SUN Yuhan
期刊论文
into nitrogen and sulfur co-doped carbon nanotubes for effective desulfurization of liquid phases: Equilibrium
期刊论文
Data quality assessment for studies investigating microplastics and nanoplastics in food products: Are
期刊论文
ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT
期刊论文
Experimental studies on extraction of cobalt ions from dilute aqueous solutions by using complexation-ultrafiltration
Jianxian ZENG, Junfeng LIU, Niandong HUANG,
期刊论文